Traditionally, indigenous American populations have been viewed as descendants of a small subset of the Eurasian population that migrated to the Western Hemisphere less than 15,000 years ago from Asia via the Bering Land Bridge. Recent archeological discoveries indicate that humans occupied high-latitude regions in Northeast Asia and Western Beringia before 30,000 years ago, prior to the Last Glacial Maximum (LGM). The early settlement of Beringia now appears part of the broader dispersal of modern humans out of Africa and across Eurasia. Recent metagenomic evidence suggests the earliest migrants south of the glaciers likely followed a coastal route rather than an interior continental path between retreating glacial masses. The merging of the increasingly rich and robust genomic (both ancient and modern), archaeological, and paleoecological records is proving to be challenging in elucidating the origin of a distinctive Native American genome in both time and space.